THRSP

Across TCGA patient cohorts, THRSP mutation is significantly associated with the RNA expression of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THRSP-associated genes across cancer lineages are RNA5SP489, HSPE1-MOB4, and RNU6-6P. Each is linked with THRSP in more than 1 cancer types. Because this analysis shows association rather than direction, both THRSP-to-partner and partner-to-THRSP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP489 grouped by THRSP-low versus THRSP-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THRSP→partner) and Y-score (partner→THRSP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNA5SP489 →	+0.428	+7.640	<.001	.009	3	2
UCEC	HSPE1-MOB4 →	+0.203	+3.432	.009	.009	3	1
UCEC	RNU6-6P →	+0.747	+4.077	.001	.001	3	1
SKCM	LINC01742 →	+0.086	+5.075	.005	.001	3	1
SKCM	MTND1P30 →	+0.057	+5.080	<.001	.004	3	1
UCEC	ATP11AUN →	+0.118	+4.066	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

RNA5SP489 by THRSP expression — BLCA

Explore this box plot interactively →