THRSP

Across TCGA cell cohorts, THRSP RNA expression is significantly associated with the go_rna of many other GO terms, with 1,331 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible THRSP-associated GO terms across cancer lineages are Regulation of amyloid fibril formation, Membrane protein ectodomain proteolysis, and Mitochondrial transmembrane transport. Each is linked with THRSP in more than 4 cancer types. Because this analysis shows association rather than direction, both THRSP-to-partner and partner-to-THRSP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of amyloid fibril formation grouped by THRSP-low versus THRSP-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (THRSP→partner) and Y-score (partner→THRSP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Regulation of amyloid fibril formation →	+0.085	+0.753	.001	.005	3	5
OESOPHAGUS	Membrane protein ectodomain proteolysis →	+0.141	+0.054	.005	.008	3	4
LUNG_SCLC	Mitochondrial transmembrane transport →	-0.112	-0.393	<.001	.001	3	4
LUNG_SCLC	Heart trabecula morphogenesis →	-0.085	-0.279	.003	.007	2	5
BLOOD_Lymphoma	Carnitine shuttle →	-0.112	-0.648	<.001	.004	3	4
CNS	Regulation of MDA-5 signaling pathway →	+0.142	+0.397	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,331 associations by consensus.

Regulation of amyloid fibril formation by THRSP expression — OVARY

Explore this box plot interactively →