THRB

Across TCGA patient cohorts, THRB mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THRB-associated genes across cancer lineages are eIF4E, ERK2, and p38-MAPK_pT180_Y182. Each is linked with THRB in more than 2 cancer types. Because this analysis shows association rather than direction, both THRB-to-partner and partner-to-THRB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by THRB-low versus THRB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THRB→partner) and Y-score (partner→THRB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.138	+2.820	.028	.001	3	3
UCEC	ERK2 →	+0.171	+1.584	.002	.002	3	3
SKCM	p38-MAPK_pT180_Y182 →	-0.331	-2.305	.009	.032	3	2
UCEC	PDCD4 →	-0.417	-1.807	.002	<.001	3	2
SKCM	SF2 →	-0.116	-1.584	.021	.032	3	2
UCEC	Caspase-8 →	-0.222	-1.807	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

eIF4E by THRB expression — UCEC

Explore this box plot interactively →