THRB

Across TCGA cell cohorts, THRB mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible THRB-associated genes across cancer lineages are MAGEB4, GALR3, and HS6ST1. Each is linked with THRB in more than 1 cancer types. Because this analysis shows association rather than direction, both THRB-to-partner and partner-to-THRB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by THRB-low versus THRB-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THRB→partner) and Y-score (partner→THRB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.011	+3.415	<.001	.001	3	1
LARGE_INTESTINE	GALR3 →	+0.104	+3.646	<.001	.002	3	1
LARGE_INTESTINE	HS6ST1 →	+0.887	+3.067	.009	.009	3	1
LARGE_INTESTINE	LMNTD1 →	+0.165	+3.455	<.001	<.001	3	1
LARGE_INTESTINE	ABCG4 →	+0.203	+3.439	.007	.003	3	1
LARGE_INTESTINE	OR52H1 →	+0.019	+2.669	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

MAGEB4 by THRB expression — LARGE_INTESTINE

Explore this box plot interactively →