THRB-AS1

Across TCGA pan-cancer cohorts, THRB-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated THRB-AS1 data layer.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher THRB-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated THRB-AS1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and BRCA show a favorable association.

UCEC, KIRC, and BRCA are the cancer types where THRB-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.787	0.881	<.001	124	view →
KIRC	DFS	Tertile	All	0.870	0.665	.001	76	view →
BRCA	OS	Median	All	0.979	0.945	.001	45	view →
SKCM	DFS	Median	All	0.243	0.161	.002	45	view →
OV	OS	Quartile	All	0.914	0.761	<.001	32	view →
UVM	DFS	Tertile	All	0.230	0.631	.020	18	view →
READ	DFS	Median	II,III,IV	0.719	0.877	.021	18	view →
LIHC	DFS	Median	II,III,IV	0.232	0.443	.019	15	view →
LGG	DFS	Median	All	0.669	0.829	.011	13	view →
LUSC	OS	Tertile	All	0.483	0.356	.010	12	view →
COAD	OS	Median	III,IV	0.813	0.606	.016	10	view →
THYM	DFS	Median	III,IV	1.000	0.542	.026	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

THRB-AS1–UCEC (DFS)

Open the UCEC breakdown →