THRAP3

Across TCGA pan-cancer cohorts, THRAP3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated THRAP3 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher THRAP3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated THRAP3 expression acts as an unfavorable survival marker, although some lineages such as COAD and LUAD show a favorable association.

COAD, LUAD, and HNSC are the cancer types where THRAP3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.887	.022	42	view →
LUAD	DFS	Quartile	III,IV	0.806	0.197	.004	35	view →
HNSC	DFS	Quartile	III,IV	0.697	0.965	.005	26	view →
GBM	DFS	Tertile	All	0.502	0.237	.025	5	view →
PDAC	DFS	Median	II,III,IV	0.328	0.491	.027	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

THRAP3–COAD (DFS)

Open the COAD breakdown →