THRAP3

Across TCGA patient cohorts, THRAP3 mutation is significantly associated with the RNA expression of many other genes, with 5,454 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THRAP3-associated genes across cancer lineages are RNA5SP412, H2AZ1, and ZFYVE19. Each is linked with THRAP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both THRAP3-to-partner and partner-to-THRAP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP412 grouped by THRAP3-low versus THRAP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THRAP3→partner) and Y-score (partner→THRAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP412 →	+0.417	+1.744	<.001	<.001	3	3
UCEC	H2AZ1 →	+0.617	+2.269	<.001	<.001	3	3
UCEC	ZFYVE19 →	+0.320	+2.758	.001	<.001	3	3
UCEC	SRP68 →	+0.381	+2.247	<.001	<.001	3	3
COAD	MRM3 →	+0.537	+3.637	<.001	.001	3	3
UCEC	HASPIN →	+0.993	+3.169	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,454 associations by consensus.

RNA5SP412 by THRAP3 expression — UCEC

Explore this box plot interactively →