THRAP3

Across TCGA cell cohorts, THRAP3 mutation is significantly associated with the RNA expression of many other genes, with 102 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible THRAP3-associated genes across cancer lineages are VSX2, SETD1B, and ZCCHC2. Each is linked with THRAP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both THRAP3-to-partner and partner-to-THRAP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VSX2 grouped by THRAP3-low versus THRAP3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THRAP3→partner) and Y-score (partner→THRAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	VSX2 →	+0.011	+2.257	.008	.009	3	1
LARGE_INTESTINE	SETD1B →	+0.667	+3.212	.003	.006	3	1
LARGE_INTESTINE	ZCCHC2 →	+0.950	+3.067	<.001	.009	3	1
LARGE_INTESTINE	RAB19 →	+1.052	+3.212	<.001	.006	3	1
LARGE_INTESTINE	INPP5E →	+0.567	+3.299	.007	.004	3	1
LARGE_INTESTINE	MAML1 →	+0.531	+3.212	.007	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 102 associations by consensus.

VSX2 by THRAP3 expression — LARGE_INTESTINE

Explore this box plot interactively →