THOP1

Across TCGA pan-cancer cohorts, THOP1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated THOP1 data layer compared with 29 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher THOP1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated THOP1 expression acts as an unfavorable survival marker, although some lineages such as BLCA show a favorable association.

HNSC, OV, and LUAD are the cancer types where THOP1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.194	0.752	<.001	48	view →
OV	OS	Median	II,III,IV	0.346	0.843	.003	18	view →
LUAD	OS	Median	All	0.423	0.676	.021	12	view →
BLCA	DFS	Median	III,IV	1.000	0.273	.035	7	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

THOP1–HNSC (OS)

Open the HNSC breakdown →