THOP1

Across TCGA pan-cancer cohorts, THOP1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated THOP1 data layer compared with 29 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher THOP1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated THOP1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

PDAC, UCEC, and LUAD are the cancer types where THOP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	III,IV	0.329	0.984	.002	26	view →
UCEC	OS	Median	III,IV	1.000	0.449	.010	18	view →
LUAD	DFS	Quartile	II,III,IV	1.000	0.726	.005	11	view →
GBM	OS	Quartile	All	0.735	0.420	.023	4	view →
HNSC	DFS	Median	IV	0.600	0.775	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

THOP1–PDAC (DFS)

Open the PDAC breakdown →