THOP1

Across TCGA patient cohorts, THOP1 mutation is significantly associated with the RNA expression of many other genes, with 3,214 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THOP1-associated genes across cancer lineages are CLPX, PBK, and SNRNP48. Each is linked with THOP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both THOP1-to-partner and partner-to-THOP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLPX grouped by THOP1-low versus THOP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THOP1→partner) and Y-score (partner→THOP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CLPX →	+0.432	+1.698	<.001	<.001	3	3
COAD	PBK →	+1.015	+3.200	.001	.009	3	3
UCEC	SNRNP48 →	+0.375	+2.544	.001	<.001	3	3
UCEC	SPATA5L1 →	+0.444	+2.695	<.001	<.001	3	3
UCEC	INTS10 →	+0.336	+2.524	.001	<.001	3	3
UCEC	KCTD9 →	+0.620	+1.917	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,214 associations by consensus.

CLPX by THOP1 expression — UCEC

Explore this box plot interactively →