THOP1

Across TCGA patient cohorts, THOP1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THOP1-associated genes across cancer lineages are mTOR_pS2448, PRDX1, and Rictor_pT1135. Each is linked with THOP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both THOP1-to-partner and partner-to-THOP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by THOP1-low versus THOP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THOP1→partner) and Y-score (partner→THOP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.122	-1.745	.008	.013	3	2
UCEC	PRDX1 →	+0.131	+1.584	.040	.017	3	2
UCEC	Rictor_pT1135 →	-0.072	-1.415	.023	.010	3	2
UCEC	4E-BP1 →	+0.322	+3.807	<.001	<.001	3	2
UCEC	C-Raf →	+0.119	+1.362	.007	.034	3	2
COAD	Lck →	+0.425	+3.195	.004	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

mTOR_pS2448 by THOP1 expression — UCEC

Explore this box plot interactively →