THOP1

Across TCGA cell cohorts, THOP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,673 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible THOP1-associated GO terms across cancer lineages are Cytoplasm protein quality control, Spindle elongation, and Spindle midzone assembly. Each is linked with THOP1 in more than 17 cancer types. Because this analysis shows association rather than direction, both THOP1-to-partner and partner-to-THOP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytoplasm protein quality control grouped by THOP1-low versus THOP1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (THOP1→partner) and Y-score (partner→THOP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Cytoplasm protein quality control →	+0.173	+1.208	<.001	<.001	3	18
LUNG_NSCLC_LUSC	Spindle elongation →	+0.247	+1.055	<.001	.002	3	18
BLOOD_Myeloma	Spindle midzone assembly →	+0.215	+0.901	.003	.006	3	18
BONE	Energy coupled proton transmembrane transport, against electrochemical gradient →	+0.099	+1.329	.003	.003	3	17
BONE	Electron transport coupled proton transport →	+0.099	+1.329	.003	.003	3	17
BONE	Mitotic spindle elongation →	+0.296	+1.324	.005	.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,673 associations by consensus.

Cytoplasm protein quality control by THOP1 expression — BONE

Explore this box plot interactively →