THOP1

Across TCGA cell cohorts, THOP1 mutation is significantly associated with the RNA expression of many other genes, with 39 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible THOP1-associated genes across cancer lineages are CD1C, OR4F4, and PABPC1L2A. Each is linked with THOP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both THOP1-to-partner and partner-to-THOP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD1C grouped by THOP1-low versus THOP1-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THOP1→partner) and Y-score (partner→THOP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CD1C →	+0.690	+3.906	.001	.009	3	2
BLOOD_Myeloma	OR4F4 →	+0.045	+4.754	.002	<.001	3	2
SKIN	PABPC1L2A →	+0.047	+4.977	<.001	.007	3	2
BLOOD_Leukemia	OR10T2 →	+0.432	+3.428	.004	<.001	3	2
BREAST	OR10K2 →	+0.047	+4.781	<.001	.003	3	2
BLOOD_Myeloma	OR11H1 →	+0.093	+4.285	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

CD1C by THOP1 expression — BLOOD_Myeloma

Explore this box plot interactively →