THOC7

Across TCGA pan-cancer cohorts, THOC7 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated THOC7 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher THOC7 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated THOC7 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, LUAD, and HNSC are the cancer types where THOC7 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.944	0.456	.001	20	view →
LUAD	OS	Median	II,III,IV	1.000	0.807	.009	14	view →
HNSC	DFS	Tertile	All	0.215	1.000	.014	12	view →
CCRCC	DFS	Tertile	IV	0.784	0.138	.024	6	view →
PDAC	OS	Quartile	II,III,IV	0.759	0.899	.034	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

THOC7–LSCC (DFS)

Open the LSCC breakdown →