THOC6

Across TCGA patient cohorts, THOC6 mutation is significantly associated with the RNA expression of many other genes, with 731 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THOC6-associated genes across cancer lineages are MIR3134, RNU6-788P, and RN7SKP192. Each is linked with THOC6 in more than 1 cancer types. Because this analysis shows association rather than direction, both THOC6-to-partner and partner-to-THOC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3134 grouped by THOC6-low versus THOC6-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THOC6→partner) and Y-score (partner→THOC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MIR3134 →	+0.760	+4.363	<.001	.007	3	2
UCEC	RNU6-788P →	+0.145	+3.140	<.001	.004	3	2
UCEC	RN7SKP192 →	+0.168	+2.260	<.001	.001	3	2
BRCA	RNU6-220P →	+0.349	+5.721	<.001	.003	3	2
BLCA	LINC02220 →	+0.237	+5.376	<.001	.001	3	2
SKCM	MIR3182 →	+0.435	+6.228	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 731 associations by consensus.

MIR3134 by THOC6 expression — BLCA

Explore this box plot interactively →