THOC6

Across TCGA patient cohorts, THOC6 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THOC6-associated genes across cancer lineages are PCNA, Acetyl-a-Tubulin-Lys40, and Ku80. Each is linked with THOC6 in more than 1 cancer types. Because this analysis shows association rather than direction, both THOC6-to-partner and partner-to-THOC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by THOC6-low versus THOC6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THOC6→partner) and Y-score (partner→THOC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.194	+1.906	.026	.016	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.439	+2.331	.032	.019	3	1
UCEC	Ku80 →	+0.305	+1.884	.001	.030	3	1
UCEC	Notch1 →	+0.160	+3.335	.004	.005	3	1
UCEC	p62 Lck ligand →	+0.495	+2.415	<.001	.003	3	1
UCEC	Rab11 →	-0.129	-1.874	.026	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

PCNA by THOC6 expression — UCEC

Explore this box plot interactively →