THOC3-AS1

Across TCGA pan-cancer cohorts, THOC3-AS1 RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated THOC3-AS1 data layer.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher THOC3-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated THOC3-AS1 expression acts as an unfavorable survival marker, although some lineages such as LUSC and CESC show a favorable association.

LUAD, LUSC, and UCS are the cancer types where THOC3-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	II,III,IV	0.004	0.751	<.001	54	view →
LUSC	OS	Tertile	II,III,IV	0.516	0.360	.012	52	view →
UCS	DFS	Tertile	III,IV	0.153	0.449	.033	36	view →
LGG	DFS	Tertile	All	0.253	0.740	<.001	27	view →
BLCA	OS	Tertile	III,IV	0.101	0.418	.001	27	view →
SKCM	OS	Tertile	IV	0.247	0.752	.004	18	view →
THCA	DFS	Tertile	II,III,IV	0.145	0.794	.001	18	view →
LIHC	OS	Tertile	All	0.271	0.708	.033	18	view →
CESC	DFS	Tertile	All	0.800	0.497	.031	12	view →
STAD	DFS	Tertile	II,III,IV	0.850	0.465	.038	9	view →
KIRC	OS	Tertile	All	0.726	0.885	.042	6	view →
UCEC	DFS	Tertile	All	0.860	0.905	.032	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

THOC3-AS1–LUAD (OS)

Open the LUAD breakdown →