THOC2

Across TCGA pan-cancer cohorts, THOC2 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated THOC2 data layer compared with 26 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher THOC2 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated THOC2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and GBM show a favorable association.

KIRP, UCEC, and SKCM are the cancer types where THOC2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.040	0.896	<.001	30	view →
UCEC	DFS	Median	II,III,IV	0.854	0.296	.008	22	view →
SKCM	OS	Median	IV	0.179	0.727	<.001	11	view →
KIRC	OS	Median	All	0.125	0.881	<.001	6	view →
GBM	DFS	Median	All	1.000	0.191	.022	6	view →
READ	DFS	Median	IV	0.082	0.619	.001	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
COAD	DFS	Median	II,III,IV	0.118	0.545	.040	4	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
SCLC	DFS	Median	All	0.888	0.595	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

THOC2–KIRP (DFS)

Open the KIRP breakdown →