THOC2

Across TCGA patient cohorts, THOC2 protein abundance is significantly associated with the RNA expression of many other genes, with 18,857 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible THOC2-associated genes across cancer lineages are DKC1, SKA1, and NDC80. Each is linked with THOC2 in more than 8 cancer types. Because this analysis shows association rather than direction, both THOC2-to-partner and partner-to-THOC2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, THOC2 versus DKC1 in HNSC, with a Pearson correlation of 0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THOC2→partner) and Y-score (partner→THOC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DKC1 →	+0.809	+0.260	<.001	<.001	3	9
LSCC	SKA1 →	+0.914	+0.263	<.001	<.001	3	9
BRCA	NDC80 →	+0.942	+0.246	<.001	<.001	3	9
HNSC	NONO →	+0.555	+0.179	<.001	<.001	3	8
GBM	CHEK1 →	+0.835	+0.324	<.001	<.001	3	8
GBM	CENPH →	+0.896	+0.337	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,857 associations by consensus.

THOC2 vs DKC1 — HNSC

Explore this scatter interactively →