THOC2

Across TCGA patient cohorts, THOC2 mutation is significantly associated with the RNA expression of many other genes, with 6,299 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THOC2-associated genes across cancer lineages are H2AC16, ROR1, and PRR29. Each is linked with THOC2 in more than 3 cancer types. Because this analysis shows association rather than direction, both THOC2-to-partner and partner-to-THOC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2AC16 grouped by THOC2-low versus THOC2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THOC2→partner) and Y-score (partner→THOC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	H2AC16 →	+0.832	+3.369	<.001	.005	3	4
UCEC	ROR1 →	+0.413	+1.595	.002	.001	3	4
UCEC	PRR29 →	-0.635	-1.619	.001	<.001	3	4
UCEC	ZBTB8A →	+0.269	+1.730	<.001	<.001	3	4
UCEC	ZRSR2 →	+0.256	+1.648	<.001	<.001	3	4
UCEC	COQ2 →	+0.345	+1.879	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,299 associations by consensus.

H2AC16 by THOC2 expression — LUAD

Explore this box plot interactively →