THOC2

Across TCGA patient cohorts, THOC2 mutation is significantly associated with the total protein of many other genes, with 66 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THOC2-associated genes across cancer lineages are Cyclin-E2, Bim, and FoxM1. Each is linked with THOC2 in more than 4 cancer types. Because this analysis shows association rather than direction, both THOC2-to-partner and partner-to-THOC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by THOC2-low versus THOC2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THOC2→partner) and Y-score (partner→THOC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Cyclin-E2 →	+0.139	+2.179	.021	.035	3	5
LUSC	Bim →	+0.346	+2.179	.009	.035	3	3
UCEC	FoxM1 →	+0.154	+1.234	.014	.001	3	3
UCEC	PCNA →	+0.246	+1.906	<.001	<.001	3	3
UCEC	ATM →	-0.363	-2.188	<.001	<.001	3	3
UCEC	Cyclin-B1 →	+0.688	+1.485	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

Cyclin-E2 by THOC2 expression — LUSC

Explore this box plot interactively →