THOC2

Across TCGA cell cohorts, THOC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,448 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible THOC2-associated GO terms across cancer lineages are Spliceosomal complex assembly, Negative regulation of gene expression via chromosomal CpG island methylation, and DNA-templated DNA replication maintenance of fidelity. Each is linked with THOC2 in more than 14 cancer types. Because this analysis shows association rather than direction, both THOC2-to-partner and partner-to-THOC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Spliceosomal complex assembly grouped by THOC2-low versus THOC2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (THOC2→partner) and Y-score (partner→THOC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Spliceosomal complex assembly →	+0.103	+0.882	<.001	<.001	3	15
LUNG_SCLC	Negative regulation of gene expression via chromosomal CpG island methylation →	+0.112	+0.671	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication maintenance of fidelity →	+0.093	+0.909	.007	.001	3	14
BONE	Microtubule polymerization →	+0.116	+0.837	<.001	<.001	3	14
SOFT_TISSUE	Microtubule polymerization or depolymerization →	+0.073	+0.530	<.001	.005	3	14
UPPER_AERODIGESTIVE_TRACT	mRNA splice site recognition →	+0.144	+1.052	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,448 associations by consensus.

Spliceosomal complex assembly by THOC2 expression — LUNG_SCLC

Explore this box plot interactively →