THOC2

Across TCGA cell cohorts, THOC2 mutation is significantly associated with the RNA expression of many other genes, with 38 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible THOC2-associated genes across cancer lineages are CCKAR, OR9K2, and APOA2. Each is linked with THOC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both THOC2-to-partner and partner-to-THOC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCKAR grouped by THOC2-low versus THOC2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THOC2→partner) and Y-score (partner→THOC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CCKAR →	+0.043	+4.409	<.001	.005	3	2
URINARY_TRACT	OR9K2 →	+0.020	+5.087	<.001	.004	3	1
CNS	APOA2 →	+0.546	+3.710	<.001	.005	3	1
CNS	GALR1 →	+0.244	+4.247	<.001	<.001	3	1
CNS	ZNF705A →	+0.089	+3.906	<.001	.003	3	1
CNS	IQCJ →	+0.448	+3.954	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

CCKAR by THOC2 expression — BLOOD_Leukemia

Explore this box plot interactively →