THOC1

Across TCGA patient cohorts, THOC1 protein abundance is significantly associated with the RNA expression of many other genes, with 19,105 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible THOC1-associated genes across cancer lineages are DKC1, TIMM8A, and PPIH. Each is linked with THOC1 in more than 8 cancer types. Because this analysis shows association rather than direction, both THOC1-to-partner and partner-to-THOC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, THOC1 versus DKC1 in UCEC, with a Pearson correlation of 0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THOC1→partner) and Y-score (partner→THOC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DKC1 →	+0.907	+0.179	<.001	<.001	3	9
LSCC	TIMM8A →	+0.800	+0.322	<.001	<.001	3	8
BRCA	PPIH →	+0.535	+0.199	<.001	.005	3	8
HNSC	NR2C2AP →	+0.891	+0.218	<.001	<.001	3	8
LSCC	RPL36A →	+0.543	+0.273	<.001	<.001	3	8
HNSC	HAUS5 →	+0.702	+0.228	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,105 associations by consensus.

THOC1 vs DKC1 — UCEC

Explore this scatter interactively →