THOC1

Across TCGA patient cohorts, THOC1 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THOC1-associated genes across cancer lineages are PKC-b-II_pS660, ATM, and eEF2. Each is linked with THOC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both THOC1-to-partner and partner-to-THOC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-b-II_pS660 grouped by THOC1-low versus THOC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THOC1→partner) and Y-score (partner→THOC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKC-b-II_pS660 →	-0.254	-2.169	.014	.003	3	3
UCEC	ATM →	-0.591	-1.765	<.001	.014	3	2
UCEC	eEF2 →	+0.380	+3.459	.004	.005	3	1
UCEC	EGFR_pY1068 →	-0.315	-2.662	<.001	<.001	3	1
UCEC	eIF4E →	+0.157	+1.415	.047	.046	3	1
UCEC	eIF4G →	+0.279	+3.169	.016	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

PKC-b-II_pS660 by THOC1 expression — UCEC

Explore this box plot interactively →