THNSL1

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, THNSL1 mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THNSL1-associated genes across cancer lineages are eIF4E, MSH2, and Notch1. Each is linked with THNSL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both THNSL1-to-partner and partner-to-THNSL1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THNSL1→partner) and Y-score (partner→THNSL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECeIF4E →+0.129+1.321.042.01232
UCECMSH2 →-0.172-1.651.013.01932
UCECNotch1 →+0.121+1.125.004.03332
UCECRad50 →-0.183-1.678.012.02132
UCECSrc_pY527 →-0.317-1.415.014.04032
UCECASNS →+0.340+1.584.001.03232
Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

Exploration