THEMIS2

Across TCGA pan-cancer cohorts, THEMIS2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated THEMIS2 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher THEMIS2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated THEMIS2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

COAD, PDAC, and HNSC are the cancer types where THEMIS2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.909	1.000	.010	72	view →
PDAC	OS	Tertile	II,III,IV	0.638	0.996	.003	15	view →
HNSC	OS	Median	All	1.000	0.484	.038	12	view →
GBM	OS	Quartile	All	0.222	0.640	.001	12	view →
UCEC	DFS	Quartile	All	0.696	0.938	.014	8	view →
LSCC	OS	Tertile	III,IV	0.918	0.537	.042	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

THEMIS2–COAD (DFS)

Open the COAD breakdown →