THEMIS2

Across TCGA patient cohorts, THEMIS2 RNA expression is significantly associated with the protein abundance of many other proteins, with 24,346 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible THEMIS2-associated proteins across cancer lineages are PLCB2, THEMIS2_T593, and CD163. Each is linked with THEMIS2 in more than 9 cancer types. Because this analysis shows association rather than direction, both THEMIS2-to-partner and partner-to-THEMIS2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, THEMIS2 versus PLCB2 in GBM, with a Pearson correlation of 0.85.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (THEMIS2→partner) and Y-score (partner→THEMIS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PLCB2 →	+0.729	+1.340	<.001	<.001	3	10
LSCC	THEMIS2_T593 →	+0.962	+1.021	<.001	<.001	3	10
GBM	CD163 →	+1.255	+1.174	<.001	<.001	3	10
HNSC	STK10 →	+0.501	+1.132	<.001	<.001	3	10
LSCC	DOCK10 →	+0.521	+0.949	<.001	<.001	3	10
HNSC	GBP5 →	+0.989	+1.118	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 24,346 associations by consensus.

THEMIS2 vs PLCB2 — GBM

Explore this scatter interactively →