THEMIS2

Across TCGA cell cohorts, THEMIS2 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible THEMIS2-associated genes across cancer lineages are GYS2, PDILT, and WDR87. Each is linked with THEMIS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both THEMIS2-to-partner and partner-to-THEMIS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GYS2 grouped by THEMIS2-low versus THEMIS2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THEMIS2→partner) and Y-score (partner→THEMIS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GYS2 →	+0.033	+3.345	<.001	.007	3	1
LARGE_INTESTINE	PDILT →	+0.006	+4.022	<.001	.006	3	1
LARGE_INTESTINE	WDR87 →	+0.021	+3.453	<.001	.009	3	1
LARGE_INTESTINE	SELENOV →	+0.058	+3.196	<.001	.007	3	1
LARGE_INTESTINE	ZNF560 →	+0.210	+3.862	<.001	.005	3	1
LARGE_INTESTINE	LACTBL1 →	+0.034	+3.632	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

GYS2 by THEMIS2 expression — LARGE_INTESTINE

Explore this box plot interactively →