THEM4

Across TCGA pan-cancer cohorts, THEM4 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated THEM4 data layer compared with 25 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher THEM4 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated THEM4 expression acts as an unfavorable survival marker, although some lineages such as PDAC and OV show a favorable association.

PDAC, CCRCC, and OV are the cancer types where THEM4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	II,III,IV	0.617	0.373	.006	21	view →
CCRCC	DFS	Quartile	All	0.660	0.945	.003	17	view →
OV	DFS	Median	All	0.942	0.664	.012	12	view →
LUAD	OS	Median	All	0.895	0.783	.029	7	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

THEM4–PDAC (OS)

Open the PDAC breakdown →