THEM4

Across TCGA patient cohorts, THEM4 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THEM4-associated genes across cancer lineages are Ku80, p62 Lck ligand, and IGFBP2. Each is linked with THEM4 in more than 1 cancer types. Because this analysis shows association rather than direction, both THEM4-to-partner and partner-to-THEM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by THEM4-low versus THEM4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THEM4→partner) and Y-score (partner→THEM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.333	+2.817	.010	.036	3	1
UCEC	p62 Lck ligand →	+0.374	+2.817	.036	.036	3	1
UCEC	IGFBP2 →	-0.921	-3.169	.009	.020	2	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Ku80 by THEM4 expression — UCEC

Explore this box plot interactively →