THEM4

Across TCGA cell cohorts, THEM4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,926 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible THEM4-associated GO terms across cancer lineages are Regulation of mitochondrial membrane permeability involved in apoptotic process, Regulation of ATP-dependent activity, and Blood coagulation, intrinsic pathway. Each is linked with THEM4 in more than 9 cancer types. Because this analysis shows association rather than direction, both THEM4-to-partner and partner-to-THEM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mitochondrial membrane permeability involved in apoptotic process grouped by THEM4-low versus THEM4-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (THEM4→partner) and Y-score (partner→THEM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Regulation of mitochondrial membrane permeability involved in apoptotic process →	+0.101	+0.751	.001	.002	3	10
UPPER_AERODIGESTIVE_TRACT	Regulation of ATP-dependent activity →	+0.089	+0.958	.001	.007	3	6
SKIN	Blood coagulation, intrinsic pathway →	-0.279	-1.691	<.001	<.001	3	6
SKIN	Neurotransmitter receptor transport →	+0.212	+1.384	<.001	<.001	3	6
BONE	Negative regulation of proteolysis →	+0.189	+2.156	<.001	<.001	3	6
LUNG_NSCLC_LUSC	Fatty acid oxidation →	+0.061	+1.628	.003	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,926 associations by consensus.

Regulation of mitochondrial membrane permeability involved in apoptotic process by THEM4 expression — LIVER

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