THEG

Across TCGA patient cohorts, THEG RNA expression is significantly associated with the go_rna of many other GO terms, with 6,956 significant associations in total. STAD shows the largest number of these associations.

The most reproducible THEG-associated GO terms across cancer lineages are Postsynapse organization, Regulation of synapse structure or activity, and Negative regulation of axonogenesis. Each is linked with THEG in more than 14 cancer types. Because this analysis shows association rather than direction, both THEG-to-partner and partner-to-THEG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Postsynapse organization grouped by THEG-low versus THEG-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (THEG→partner) and Y-score (partner→THEG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Postsynapse organization →	+0.038	+0.168	<.001	<.001	3	15
ESCA	Regulation of synapse structure or activity →	+0.038	+0.510	.002	.001	2	15
ESCA	Negative regulation of axonogenesis →	+0.050	+0.591	<.001	<.001	3	13
STAD	Epithelial to mesenchymal transition →	+0.082	+0.251	<.001	<.001	3	13
STAD	Regulation of axonogenesis →	+0.066	+0.246	<.001	<.001	3	12
ESCA	Regulation of dendritic spine development →	+0.045	+0.764	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,956 associations by consensus.

Postsynapse organization by THEG expression — STAD

Explore this box plot interactively →