THEG

Across TCGA patient cohorts, THEG mutation is significantly associated with the RNA expression of many other genes, with 2,004 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THEG-associated genes across cancer lineages are LOXL1, IPPKP1, and CCL4. Each is linked with THEG in more than 3 cancer types. Because this analysis shows association rather than direction, both THEG-to-partner and partner-to-THEG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LOXL1 grouped by THEG-low versus THEG-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THEG→partner) and Y-score (partner→THEG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	LOXL1 →	-0.938	-3.430	.002	.005	3	3
LGG	IPPKP1 →	+0.056	+5.846	<.001	.003	3	3
UCEC	CCL4 →	+0.870	+2.815	.001	.001	3	3
COAD	IGHVII-62-1 →	+0.198	+4.335	<.001	.005	3	3
UCEC	RMC1 →	+0.523	+3.280	<.001	<.001	3	3
UCEC	RNU6-1213P →	+0.161	+3.292	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,004 associations by consensus.

LOXL1 by THEG expression — SKCM

Explore this box plot interactively →