THEG

Across TCGA cell cohorts, THEG RNA expression is significantly associated with the go_rna of many other GO terms, with 1,044 significant associations in total. BONE shows the largest number of these associations.

The most reproducible THEG-associated GO terms across cancer lineages are Regulation of syncytium formation by plasma membrane fusion, Negative regulation of DNA-templated transcription initiation, and Negative regulation of transcription initiation by RNA polymerase II. Each is linked with THEG in more than 6 cancer types. Because this analysis shows association rather than direction, both THEG-to-partner and partner-to-THEG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of syncytium formation by plasma membrane fusion grouped by THEG-low versus THEG-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (THEG→partner) and Y-score (partner→THEG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Regulation of syncytium formation by plasma membrane fusion →	+0.070	+0.607	<.001	.002	3	7
BONE	Negative regulation of DNA-templated transcription initiation →	+0.136	+0.354	<.001	.002	3	7
BONE	Negative regulation of transcription initiation by RNA polymerase II →	+0.136	+0.354	<.001	.002	3	7
SOFT_TISSUE	Lipoprotein transport →	+0.091	+0.248	<.001	.005	3	6
LUNG_SCLC	Positive regulation of protein export from nucleus →	+0.064	+1.108	.004	.005	3	6
UPPER_AERODIGESTIVE_TRACT	Proton motive force-driven mitochondrial ATP synthesis →	+0.115	+0.734	<.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,044 associations by consensus.

Regulation of syncytium formation by plasma membrane fusion by THEG expression — BREAST

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