THEG

Across TCGA cell cohorts, THEG mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible THEG-associated genes across cancer lineages are OR6B1, AIPL1, and PLEKHS1. Each is linked with THEG in more than 1 cancer types. Because this analysis shows association rather than direction, both THEG-to-partner and partner-to-THEG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6B1 grouped by THEG-low versus THEG-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THEG→partner) and Y-score (partner→THEG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	OR6B1 →	+0.013	+4.906	<.001	.006	3	1
LARGE_INTESTINE	AIPL1 →	+0.071	+3.554	.003	.007	3	1
BLOOD_Leukemia	PLEKHS1 →	+0.074	+3.551	<.001	.008	3	1
BLOOD_Leukemia	CALHM4 →	+0.024	+3.684	<.001	.004	3	1
BLOOD_Leukemia	PROP1 →	+0.018	+3.289	.004	.009	3	1
BLOOD_Leukemia	DEFB125 →	+0.028	+3.475	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

OR6B1 by THEG expression — OESOPHAGUS

Explore this box plot interactively →