THBS4

Across TCGA pan-cancer cohorts, THBS4 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated THBS4 data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher THBS4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated THBS4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

LUAD, BRCA, and MESO are the cancer types where THBS4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.158	0.835	<.001	18	view →
BRCA	OS	Median	All	0.413	0.924	.015	12	view →
MESO	DFS	Median	III,IV	0.078	0.376	.012	9	view →
READ	DFS	Median	All	0.111	0.799	.001	6	view →
SCLC	OS	Median	All	0.082	0.822	<.001	6	view →
UCEC	DFS	Median	All	0.945	0.828	.026	4	view →
LGG	DFS	Median	All	0.224	0.728	.025	3	view →
STAD	DFS	Median	All	0.830	0.383	.036	2	view →
SKCM	OS	Median	II,III,IV	0.959	0.827	.022	2	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

THBS4–LUAD (OS)

Open the LUAD breakdown →