THBS4

Across TCGA pan-cancer cohorts, THBS4 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated THBS4 data layer compared with 24 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher THBS4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated THBS4 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

CCRCC, LSCC, and LUAD are the cancer types where THBS4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.451	1.000	.008	10	view →
LSCC	OS	Median	II,III,IV	0.883	1.000	.019	8	view →
LUAD	OS	Tertile	II,III,IV	1.000	0.455	.022	2	view →
HNSC	DFS	Median	III,IV	1.000	0.939	.043	1	view →
PDAC	OS	Tertile	All	0.898	0.784	.020	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

THBS4–CCRCC (DFS)

Open the CCRCC breakdown →