THBS4

Across TCGA patient cohorts, THBS4 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THBS4-associated genes across cancer lineages are Caspase-7-cleavedD198, Rictor_pT1135, and 4E-BP1. Each is linked with THBS4 in more than 2 cancer types. Because this analysis shows association rather than direction, both THBS4-to-partner and partner-to-THBS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by THBS4-low versus THBS4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THBS4→partner) and Y-score (partner→THBS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.972	+2.700	<.001	<.001	3	3
STAD	Rictor_pT1135 →	-0.165	-3.000	.016	.033	3	2
UCEC	4E-BP1 →	+0.328	+2.807	<.001	.002	3	2
UCEC	eIF4E →	+0.160	+3.183	.019	.009	3	2
UCEC	JNK2 →	+0.175	+2.348	.006	.018	3	2
UCEC	MEK1 →	+0.416	+2.906	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Caspase-7-cleavedD198 by THBS4 expression — UCEC

Explore this box plot interactively →