THBS4

Across TCGA cell cohorts, THBS4 mutation is significantly associated with the RNA expression of many other genes, with 241 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible THBS4-associated genes across cancer lineages are C16orf92, RTP2, and MCAT. Each is linked with THBS4 in more than 1 cancer types. Because this analysis shows association rather than direction, both THBS4-to-partner and partner-to-THBS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C16orf92 grouped by THBS4-low versus THBS4-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THBS4→partner) and Y-score (partner→THBS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	C16orf92 →	+0.061	+4.947	<.001	.001	3	1
LUNG_NSCLC_LUAD	RTP2 →	+0.030	+4.371	.006	.005	3	1
LARGE_INTESTINE	MCAT →	+0.664	+3.364	.001	.002	3	1
LARGE_INTESTINE	USP14 →	+0.765	+3.087	<.001	.006	3	1
LARGE_INTESTINE	CEP76 →	+0.694	+3.364	.002	.002	3	1
LARGE_INTESTINE	CA2 →	+2.048	+3.364	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 241 associations by consensus.

C16orf92 by THBS4 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →