THBS3-AS1

Across TCGA pan-cancer cohorts, THBS3-AS1 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated THBS3-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher THBS3-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated THBS3-AS1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and SKCM show a favorable association.

KIRC, ACC, and UVM are the cancer types where THBS3-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.547	0.700	<.001	121	view →
ACC	DFS	Median	All	0.263	0.606	<.001	95	view →
UVM	DFS	Median	III,IV	0.249	0.810	<.001	78	view →
KICH	OS	Quartile	All	0.610	1.000	.001	76	view →
COAD	OS	Median	All	0.716	0.883	<.001	73	view →
BRCA	OS	Median	All	0.642	0.517	.001	61	view →
SKCM	OS	Tertile	II,III,IV	0.538	0.294	.001	58	view →
CHOL	DFS	Median	II,III,IV	0.121	0.626	.002	27	view →
PRAD	DFS	Tertile	All	0.695	0.834	<.001	26	view →
MESO	OS	Median	All	0.304	0.665	.018	21	view →
PAAD	OS	Quartile	All	0.743	0.551	.016	11	view →
CESC	DFS	Quartile	All	0.787	0.907	.007	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

THBS3-AS1–KIRC (OS)

Open the KIRC breakdown →