Across TCGA patient cohorts, THBS2 mutation is significantly associated with the RNA expression of many other genes, with 6,436 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THBS2-associated genes across cancer lineages are NOCT, NCAPG, and OTX1. Each is linked with THBS2 in more than 4 cancer types. Because this analysis shows association rather than direction, both THBS2-to-partner and partner-to-THBS2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THBS2→partner) and Y-score (partner→THBS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NOCT →	+0.567	+1.470	<.001	<.001	3	5
UCEC	NCAPG →	+0.545	+1.636	<.001	<.001	3	4
COAD	OTX1 →	+0.464	+1.868	.002	.004	3	4
COAD	MDM2 →	+0.537	+3.847	<.001	<.001	3	4
UCEC	CHEK1 →	+0.354	+1.131	.004	.002	3	4
UCEC	MCU →	+0.320	+1.273	.002	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,436 associations by consensus.

Exploration

THBS2 survival (RNA) · tumor vs normal (RNA) · all THBS2 data types