Across TCGA patient cohorts, THBS2 mutation is significantly associated with the total protein of many other genes, with 68 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THBS2-associated genes across cancer lineages are 4E-BP1, eEF2, and ASNS. Each is linked with THBS2 in more than 4 cancer types. Because this analysis shows association rather than direction, both THBS2-to-partner and partner-to-THBS2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THBS2→partner) and Y-score (partner→THBS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	4E-BP1 →	+0.433	+3.000	.002	.034	3	5
UCEC	eEF2 →	+0.204	+1.362	.025	.031	3	5
LUAD	ASNS →	+0.683	+3.321	<.001	.009	3	4
UCEC	eIF4E →	+0.183	+1.862	<.001	<.001	3	4
UCEC	Caspase-7-cleavedD198 →	+0.627	+1.827	<.001	<.001	3	4
UCEC	MEK1 →	+0.414	+1.862	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

Exploration

THBS2 survival (RNA) · tumor vs normal (RNA) · all THBS2 data types