Across TCGA cell cohorts, THBS2 mutation is significantly associated with the RNA expression of many other genes, with 1,018 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible THBS2-associated genes across cancer lineages are PAPOLG, RPF1, and PDS5A. Each is linked with THBS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both THBS2-to-partner and partner-to-THBS2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THBS2→partner) and Y-score (partner→THBS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PAPOLG →	+0.352	+3.067	.007	.009	3	2
LARGE_INTESTINE	RPF1 →	+0.889	+3.829	<.001	<.001	3	2
LARGE_INTESTINE	PDS5A →	+0.718	+2.628	<.001	.002	3	2
LARGE_INTESTINE	TTC5 →	+0.619	+2.628	.004	.002	3	2
LARGE_INTESTINE	COPS3 →	+0.534	+2.628	.005	.002	3	2
LARGE_INTESTINE	WRAP53 →	+0.559	+2.628	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,018 associations by consensus.

Exploration

THBS2 survival (RNA) · tumor vs normal (RNA) · all THBS2 data types