THBS1

Across TCGA pan-cancer cohorts, THBS1 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated THBS1 data layer compared with 27 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher THBS1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated THBS1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LGG show a favorable association.

ESCA, UCEC, and SKCM are the cancer types where THBS1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.108	0.703	<.001	36	view →
UCEC	DFS	Median	All	0.952	0.612	.004	22	view →
SKCM	OS	Median	All	0.663	0.880	.002	15	view →
BLCA	OS	Median	All	0.188	0.687	.020	12	view →
KIRC	DFS	Median	All	0.266	0.796	.020	6	view →
LIHC	OS	Median	All	0.258	0.710	.012	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
LGG	OS	Median	All	1.000	0.420	.018	4	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
COAD	DFS	Median	II,III,IV	0.529	0.748	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

THBS1–ESCA (OS)

Open the ESCA breakdown →