THBS1

Across TCGA pan-cancer cohorts, THBS1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated THBS1 data layer compared with 27 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher THBS1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated THBS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

PDAC, LUAD, and COAD are the cancer types where THBS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.205	0.397	.009	23	view →
LUAD	DFS	Quartile	All	0.380	0.773	.006	16	view →
COAD	DFS	Median	IV	0.493	0.944	.031	6	view →
HNSC	OS	Quartile	IV	0.904	0.653	.014	6	view →
CCRCC	DFS	Median	II,III,IV	0.199	0.839	.011	5	view →
LSCC	OS	Tertile	All	0.758	0.884	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

THBS1–PDAC (DFS)

Open the PDAC breakdown →