THBD

Across TCGA pan-cancer cohorts, THBD mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated THBD data layer compared with 27 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher THBD mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated THBD expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

PDAC, HNSC, and GBM are the cancer types where THBD mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.556	0.937	<.001	77	view →
HNSC	OS	Median	All	0.830	0.607	.003	17	view →
GBM	OS	Median	All	0.776	0.959	.012	7	view →
COAD	DFS	Median	All	0.910	1.000	.026	6	view →
CCRCC	OS	Tertile	III,IV	0.475	0.837	.016	5	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

THBD–PDAC (DFS)

Open the PDAC breakdown →