THAP9

Across TCGA patient cohorts, THAP9 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THAP9-associated genes across cancer lineages are PDCD4, VHL, and ATM. Each is linked with THAP9 in more than 1 cancer types. Because this analysis shows association rather than direction, both THAP9-to-partner and partner-to-THAP9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by THAP9-low versus THAP9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THAP9→partner) and Y-score (partner→THAP9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.455	-1.874	.011	.049	3	2
UCEC	VHL →	-0.953	-2.415	<.001	.003	3	2
UCEC	ATM →	-0.572	-2.446	<.001	.018	3	2
UCEC	Cyclin-B1 →	+0.743	+2.584	<.001	.001	3	2
UCEC	14-3-3_beta →	-0.108	-3.432	.004	.005	3	1
UCEC	eEF2 →	+0.353	+1.678	.010	.023	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

PDCD4 by THAP9 expression — UCEC

Explore this box plot interactively →