THAP9

Across TCGA cell cohorts, THAP9 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible THAP9-associated genes across cancer lineages are OR11H1, C14orf177, and OR4M1. Each is linked with THAP9 in more than 1 cancer types. Because this analysis shows association rather than direction, both THAP9-to-partner and partner-to-THAP9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR11H1 grouped by THAP9-low versus THAP9-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THAP9→partner) and Y-score (partner→THAP9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR11H1 →	+0.045	+5.201	.002	.006	3	1
BLOOD_Leukemia	C14orf177 →	+0.069	+4.922	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR4M1 →	+0.006	+4.266	<.001	.004	3	1
LUNG_NSCLC_LUAD	CCER1 →	+0.045	+3.343	.002	.005	3	1
LUNG_NSCLC_LUAD	FAM90A26 →	+0.015	+3.481	.002	.004	3	1
LUNG_NSCLC_LUAD	PRAMEF6 →	+0.034	+3.362	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

OR11H1 by THAP9 expression — BLOOD_Leukemia

Explore this box plot interactively →